RAG Deficiency: Two Genes, Many Diseases
نویسندگان
چکیده
منابع مشابه
RAG - I 1 and RAG - 2 , Adjacent Genes That Synergistically
The vast repertoire of immunoglobulins and T cell receptors is generated, in part, by V(D)J recombination, a series of genomic rearrangements that occur specifically in developing lymphocytes. The recombination activating gene, RAG-1, which is a gene expressed exclusively in maturing lymphoid cells, was previously isolated. RAG-1 inefficiently induced V(D)J recombinase activity when transfected...
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ژورنال
عنوان ژورنال: Journal of Clinical Immunology
سال: 2018
ISSN: 0271-9142,1573-2592
DOI: 10.1007/s10875-018-0537-4